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Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells

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Abstract:

Evidence of Mycoplasma hyorhinis infection in human gastric cancer tissues has been found in previous work. In this study, we demonstrate that the expression of p37, a membrane lipoprotein of M. hyorhinis, in mammalian cells induces antisenescence, enhances clonogenicity in soft agar, and co-operates with human epidermal growth factor receptor-related 2 to inhibit cell adhesion. Conversely, truncated p37 protein, with the first 28 amino acids deleted from its N terminal, promotes cell senescence. Taken together, our findings suggest that p37 promotes malignant changes in mammalian cells. With the identification of this molecular component, which is responsible for mycoplasma malignancy-promoting activity, it is possible that a better understanding of the relationship between M. hyorhinis infection and human gastric cancers will lead to novel diagnostics and therapeutics.

Lors d’une étude précédente, une infection par Mycoplasma hyorhinis avait été mise en évidence dans des tissus gastriques cancéreux humains. Dans cette étude, nous démontrons que l’expression dans les cellules mammifères de p37, une lipoprotéine membranaire de M. hyorhinis, induit une anti-sénescence, augmente la clonogénicité en agar mou, et coopère avec le human epidermal growth factor receptor-related 2 pour inhiber l’adhésion cellulaire. À l’inverse, la protéine p37 tronquée, où les 28 premiers acides aminés de son extrémité N-terminale sont enlevés, favorise la sénescence cellulaire. En somme, nos résultats suggèrent que p37 favorise les changements malins dans les cellules mammifères. Avec l’identification de cette composante moléculaire responsable de l’activité favorisant la malignité exercée par le mycoplasme, une meilleure compréhension des relations qui existent entre l’infection par M. hyorhinis et les cancers gastriques chez l’humain pourra conduire à de nouveaux outils diagnostiques et thérapeutiques.

Document Type: Research Article

Publication date: February 1, 2007

More about this publication?
  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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