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Expression of CaPTC7 is developmentally regulated during serum-induced morphogenesis in the human fungal pathogen Candida albicans

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Type 2C protein phosphatases (PP2C) represent a diversified protein phosphatase family and play various roles in cells. We previously identified and characterized a novel PP2C phosphatase encoded by the CaPTC7 gene in the human fungal pathogen Candida albicans. The CaPtc7p has 365 amino acids with a PP2C core domain at the C terminus and an additional 116-residue N-terminal sequence containing a mitochondrion-targeting sequence. Here, we show that CaPtc7p is indeed localized in the mitochondrion, the only eukaryotic PP2C phosphatase that has been directly shown to reside in the mitochondrion, suggesting its potential role in the regulation of mitochondrial physiology. Furthermore, we show that the expression of CaPTC7 at both transcriptional and protein levels is developmentally regulated during the serum-induced morphogenesis of C. albicans cells. However, disruption of the two alleles of CaPTC7 does not affect cell viability or filamentous development in C. albicans.

Les protéine-phosphatases de type 2C (PP2C) représentent une famille diversifiée de phosphatases qui jouent divers rôles dans les cellules. Nous avons précédemment identifié et caractérisé une nouvelle phosphatase PP2C codée par le gène CaPTC7 chez le champignon pathogène de l’humain Candida albicans. CaPtc7p possède 365 acides aminés, incluant un domaine PP2C à l’extrémité C-terminale ainsi qu’une séquence additionnelle de 116 résidus à l’extrémité N-terminale qui contient une séquence de ciblage mitochondrial. Nous montrons ici que CaPtc7p est effectivement localisée dans la mitochondrie, la seule phosphatase PP2C eucaryote don't on a démontré directement qu’elle résidait dans la mitochondrie, suggérant qu’elle ait un rôle potentiel dans la régulation de la physiologie mitochondriale. Qui plus est, nous montrons que l’expression de CaPTC7 est régulée en fonction du développement, tant au niveau de la transcription qu’au niveau de la protéine, lors de la morphogenèse induite par le sérum des cellules de C. albicans. Cependant, l’inactivation des deux allèles de CaPTC7 n’affecte pas la viabilité cellulaire ou le développement filamenteux de C. albicans.

Document Type: Research Article

Publication date: 2007-02-01

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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