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Studies on antimicrobial activity of cobalt(III) ethylenediamine complexes

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A series of cobalt(III) mixed ligand complexes of type [Co(en)2L]+3, where L is bipyridine, 1,10-phenanthroline, imidazole, methylimidazole, ethyleimidazole, dimethylimidazole, urea, thiourea, acetamide, thioacetamide, semicarbazide, thiosemicarbazide, or pyrazole, have been isolated and characterized. The structural elucidation of these complexes has been explored by using absorption, infrared, and 1H NMR nuclear magnetic resonance spectral methods. The infrared spectral data of all these complexes exhibit a band at 1450/cm and 1560–1590/cm, which correspond to C = C and C = N, a band at 575/cm for Co-N (en), and a band at 480/cm for Co-L (ligand). All these complexes were found to be potent antimicrobial agents. The antibacterial activity was studied in detail in terms of zone inhibition, minimum bactericidal, and time period of lethal action. Among all, complexes bipyridine, 1,10-phenanthroline, dimethylimidazole, and pyrazole, possess the highest antibacterial activity. Antifungal activity was done by disc-diffusion assay and 50% inhibitory concentrations that possess high antifungal activity.Key words: cobalt(III) complexes, ethylenediamine, antimicrobial, antifungal.

Une série de complexes mixtes de ligands du cobalt(III) de type [Co(en)2L]+3, où L est bipyridine, 1,10-phénanthroline, imidazole, méthylimidazole, éthyleimidazole, diméthylimidazole, urée, thiourée, acétamide, thioacétamide, semicarbazide, thiosemicarbazideet pyrazole ont été isolés et caractérisés. L'élucidation de la structure de ces complexes fut explorée en utilisant les méthodes spectrales d'absorption, d'IR et de RMN 1H. Les données d'IR spectral de tous ces complexes ont affiché une bande à 1450/cm et 1560–1590/cm qui correspondaient à C = C et C = N, une bande à 575/cm pour Co-N (en) et à 480/cm pour Co-L (ligand). Tous ces complexes ont démontré un potentiel antimicrobien. L'activité antibactérienne fut étudiée en détails en termes de zone d'inhibition, d'activité bactéricide minimale et de durée de l'action létale. Parmi tous les complexes, bipyridine, 1,10-phénanthroline, diméthylimidazole et pyrazole possédaient les activités antibactériennes les plus élevées. L'activité antifongique fut mesurée par la méthode des disques et les concentrations IC50 furent déterminées pour ceux possédant des activités antifongiques élevées.Mots clés : complexes cobalt(III), éthylènediamine, antimicrobien, antifongique.[Traduit par la Rédaction]

Document Type: Research Article

Publication date: December 1, 2006

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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