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Actinobacillus actinomycetemcomitans serotype-specific genotypes and periodontal status in Brazilian subjects

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Periodontitis is associated with members of the oral microbiota, such as Actinobacillus actino mycetem comitans. To our knowledge, this is the first study to evaluate, by PCR, the occurrence of the six known bacterium serotypes that included subjects with and without periodontitis. Our group comprised 49 Brazilian subjects. We studied 146 bacterial isolates from 23 patients with aggressive or chronic periodontitis and 26 subgingival specimens from subjects with or without periodontitis, all originating in our collection. Serotypes b and c were observed in similar frequencies, and no subject harboured d, e, or f serotype strains. Around 78% subjects had single-serotype infection. Mixed infection was seen only in aggressive periodontitis patients. An association between serotype b and healthy periodontium and between serotype c and chronic periodontitis was observed. Our results diverge from those previously reported, which may be explained by specific distribution patterns in distinct populations. The association of different serotypes with the same periodontal status or conversely of a serotype with different periodontal conditions indicates that organism serotyping should not be used as a sole reliable marker for predicting the outcome of the infection. Evaluation of factors involved in human oral cavity colonization by subsets of A. actinomycetemcomitans is essential for elucidating organism-host-environment relationships.Key words: Actinobacillus actinomycetemcomitans, genotyping, serotyping, periodontitis.

La parodontite est associée avec des membres de la microflore orale tels que Actinobacillus actinomycetemcomitans. À notre connaissance, ceci est la première étude à évaluer par PCR la présence de six sérotypes connus de bactéries chez des sujets avec ou sans parodontite. Notre groupe comprenait 49 sujets brésiliens. Nous avons étudié 146 isolats bactériens isolés de 23 patients souffrant de parodontite agressive ou chronique et 26 spécimens sous-gingivaux de sujets avec ou sans parodontite provenant de notre collection. Les sérotypes b et c furent observées à des fréquences semblables et aucun sujet n'était porteur de souches de sérotype d, e ou f. Environ 78 % des sujets avaient une infection à sérotype simple. Une infection mixte ne fut notée que chez des patients à parodontite agressive. Nous avons observé une association entre le sérotype b et un parondonte sain et entre le sérotype c et une parodontite chronique. L'association entre différents sérotype avec le même statut parodontal ou à l'inverse d'un sérotype avec différentes conditions parodontales indiquent que le sérotypage d'organismes ne devrait pas être utilisé comme seul marqueur fiable pour déterminer le pronostic de l'infection. L'évaluation de facteurs impliqués dans la colonisation de la cavité orale humaine par des sous-ensembles de A. actinomycetemcomitans est essentielle afin d'élucider la relation organisme–hôte–environnement.Mots clés : Actinobacillus actinomycetemcomitans, génotypage, sérotypage, parodontite.[Traduit par la Rédaction]

Document Type: Research Article

Publication date: March 1, 2006

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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