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The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans

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Abstract:

Farnesol, a quorum sensing (QS) signal, is produced by Candida albicans during high density growth and has been found to inhibit morphogenesis. This QS auto-inducing signal was discovered to increase amino acid incorporation by C. albicans when concentrations of farnesol increased to 10 µg/mL in yeast nitrogen broth. Farnesol concentrations greater than 10 µg/mL abolished the enhanced incorporation, and the magnitude of the increased incorporation was dependent on cell-surface hydrophobicity.Key words: Candida albicans, farnesol, amino acid incorporation.

Le farnésol, un signal de sensibilité au quorum (SQ), est produit par Candida albicans lors de sa croissance à densité élevée et a démontré une action inhibitrice sur la morphogénèse. Nous avons constaté que le signal auto-inducteur du SQ augmentait l'incorporation d'acides aminés chez C. albicans lorsque les concentrations de farnésol augmentaient jusqu'à 10 µg/mL dans le milieu yeast nitrogen broth. Des concentrations de farnésol supérieures à 10 µg/mL ont supprimé l'augmentation de l'incorporation et la magnitude de celle-ci dépendait de l'hydrophobicité de la surface cellulaire.Mots clés : Candida albicans, farnésol, incorporation d'acides aminés.[Traduit par la Rédaction]

Document Type: Research Article

Publication date: August 1, 2005

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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