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Interspecies communication between Burkholderia cepacia and Pseudomonas aeruginosa

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Abstract:

Burkholderia cepacia and Pseudomonas aeruginosa are opportunistic pathogens that commonly cause pulmonary infections in cystic fibrosis patients and occasionally co-infect patients' lungs. Both organisms possess quorum-sensing systems dependent on N-acyl homoserine lactone (N-acyl-HSL). Cross-feeding assays demonstrated that P. aeruginosa and B. cepacia were able to utilize heterologous N-acyl-HSL signaling molecules. The ability of quorum-sensing genes from one species to complement the respective quorum-sensing mutations in the heterologous species was also examined. These studies suggest that B. cepacia CepR can use N-acyl-HSLs synthesized by RhlI and LasI and that P. aeruginosa LasR and RhlR can use N-acyl-HSLs synthesized by CepI. It is possible that a mixed bacterial population of B. cepacia and P. aeruginosa can coordinately regulate some of their virulence factors and influence the progression of lung disease due to infection with these organisms.Key words: quorum sensing, Burkholderia cepacia, Pseudomonas aeruginosa, cystic fibrosis.

Burkholderia cepacia et Pseudomonas aeruginosa sont des pathogènes opportunistes qui causent habituellement des infections pulmonaires chez des patients atteints de fibrose kystique et peuvent parfois co-infecter les poumons de ces patients. Les deux organismes possèdent des systèmes sensibles au quorum dépendants du N-acyl homosérine lactone (N-acyl-HSL). Des essais d'alimentation croisée ont démontré que P. aeruginosa et B. cepacia étaient capables d'utiliser des molécules N-acyl-HSL de signalisation hétérologues. Nous avons également étudié la capacité de gènes de sensibilité au quorum d'une espèce à complémenter les mutations respectives dans les gènes de sensibilité au quorum de l'espèce hétérologue. Ces études ont indiqué que B. cepacia CepR pouvait utiliser les N-acyl-HSL synthétisés par RhlI et LasI, et que P. aeruginosa LasR et RhlI peuvent utiliser les N-acyl-HSL synthétisés par CepI. Il est concevable que des populations bactériennes mixtes de B. cepacia et de P. aeruginosa peuvent coordonner la régulation de leurs facteurs de virulence et influencer la progression des troubles pulmonaires attribuables une l'infection par ces organismes.Mots clés : sensibilité au quorum, Burkholderia cepacia, Pseudomonas aeruginosa, fibrose kystique.[Traduit par la Rédaction]

Keywords: Burkholderia cepacia; Pseudomonas aeruginosa; au quorum; cystic fibrosis; fibrose kystique; quorum sensing; sensibilité

Document Type: Research Article

Publication date: August 1, 2002

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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