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Plasmid-borne AmpC b-lactamases

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Historically, it was thought that ampC genes encoding class C β-lactamases were located solely on the chromosome but, within the last 12 years, an increasing number of ampC genes have been found on plasmids. These have mostly been acquired by ampC-deficient pathogenic bacteria, which consequently are supplied with new and additional resistance phenotypes. This review discusses the phylogenetic origin of the plasmid-encoded AmpC β-lactamases, their occurrence, and mode of spread, as well as their hydrolytic properties.Key words: AmpC b-lactamases, plasmid-encoded, phylogeny, dissemination.

Historiquement, on considérait que les gènes ampC responsables des β-lactamases étaient uniquement localisés sur le chromosome, mais depuis au moins 12 ans, un nombre important de gènes ampC ont été retrouvés sur des plasmides. Ces plasmides ont la plupart du temps été acquis par des bactéries pathogènes ampC-déficientes qui deviennent à leur tour des nouveaux phénotypes résistants. Cette revue discute de l'origine phylogénétique des β- lactamases AmpC d'origine plasmidique. Nous discutons aussi de leur fréquence, de leur mode de propagation ainsi que de leurs propriétés d'hydrolyse.Mots clés : b-lactamases AmpC, support plasmidique, phylogénie, dissémination.[Traduit par la Rédaction]

Keywords: b-lactamases AmpC; AmpC b-lactamases; dissemination; dissémination; phylogeny; phylogénie; plasmid-encoded; support plasmidique

Document Type: Research Article

Publication date: 2002-06-01

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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