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Effect of fur mutation on acid-tolerance response and in vivo virulence of avian septicemic Escherichia coli

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The Fur (ferric uptake regulator) protein is a master regulator of iron metabolism in gram-negative bacteria. In the present study, the effect of a partial deletion of the fur gene on the acid-tolerance response and in vivo virulence of avian Escherichia coli was examined. The fur mutant was unable to trigger the acid-tolerance response as observed in the wild-type parent strain. However, the mutant was as virulent as the wild-type parent strain when tested in 1-day-old chickens by subcutaneous inoculation. These data indicate that the fur gene is involved in the acid-tolerance response but not involved in the virulence of E. coli, as detected by the ability to cause septicemia in our experimental infection.Key words: E. coli, fur, acid-tolerance response.

La protéine Fur (régulateur de la captation du fer) est une protéine-clé de régulation dans le métabolisme du fer chez les bactéries gram-négatives. Cette étude a cherché à mesurer l'effet d'une délétion partielle du gène fur sur la réponse de tolérance acide et sur la virulence in vivo d'Escherichia coli d'origine aviaire. Le mutant fur a été incapable de provoquer cette tolérance acide comme c'était le cas de la souche parentale sauvage. Par contre le mutant était aussi virulent que la souche parentale lorsqu'inoculé par voie sous-cutanée chez des poulets âgés d'un jour. Ces résultats confirment que le gène fur est impliqué dans la réponse de tolérance acide mais qu'il n'est pas impliqué dans la virulence d'E. coli qui conserve sa capacité à causer une septicémie dans notre modèle expérimental d'infection.Mots clés : E. coli, fur, réponse de tolérance acide.[Traduit par la Rédaction]

Keywords: E. coli; acid-tolerance response.; fur

Document Type: Research Article

Publication date: 2002-05-01

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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