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Effect of amino acids on thaxtomin A biosynthesis by Streptomyces scabies

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The regulatory effect of amino acids on the production of thaxtomin A, a phytotoxin produced by Streptomyces scabies, was investigated. Tryptophan had an important inhibitory effect on the toxin biosynthesis in all five strains of S. scabies tested. Two other aromatic amino acids (tyrosine and phenylalanine) also inhibited thaxtomin A biosynthesis, while aliphatic amino acids did not cause an important decline in thaxtomin A production. Methylation of tryptophan prevented or reduced the inhibitory effect on thaxtomin A biosynthesis. In spite of the inhibitory action of tryptophan and phenylalanine on thaxtomin A production, incorporation of these radiolabeled molecules into thaxtomin A confirmed that they are metabolic precursors for the biosynthesis of the phytotoxin.Key words: thaxtomin A, phytotoxin, Streptomyces scabies, common scab, nitroaromatic compounds, amino acids.

Nous avons étudié l'effet régulateur des acides aminés sur la production de thaxtomine A, une phytotoxine produite par par Streptomyces scabies. Le tryptophane a eu un effet inhibiteur prononcé sur la biosynthèse de la toxine chez les cinq souches de S. scabies analysées. Deux autres acides aminés aromatiques (tyrosine et phénylalanine) ont également inhibé la biosynthèse de la thaxtomine A, alors que les acides aminés aliphatiques n'ont pas occasionné de déclin important dans la production de thaxtomine A. La méthylation du tryptophane a empêché ou diminué l'effet inhibiteur sur la biosynthèse de la thaxtomine A. Malgré l'effet inhibiteur du tryptophane et de la phénylalanine sur la production de thaxtomine A, l'incorporation de molécules radiomarquées dans la thaxtomine A a confirmé que ceux-ci étaient des précurseurs métaboliques de la biosynthèse de la phytotoxine.Mots clés : thaxtomine A, phytotoxine, Streptomyces scabies, gale commune, composés nitroaromatiques, acides aminés.[Traduit par la Rédaction]

Keywords: Streptomyces scabies; acides aminés; amino acids; common scab; composés nitroaromatiques; gale commune; nitroaromatic compounds; phytotoxin; phytotoxine; thaxtomin A; thaxtomine A

Document Type: Research Article

Publication date: April 1, 2002

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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