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IgA and IgM anti-Naegleria fowleri antibodies in human serum and saliva

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Abstract:

Antibodies from IgA and IgM classes that recognize Naegleria fowleri (Nf) proteins were detected by the ELISA assay in serum and saliva from three groups of people: (i) subjects with upper respiratory tract infections (URTI) living in the parasite-endemic area, (ii) healthy persons from the same area, and (iii) healthy persons from a parasite-nonendemic area. In serum and in saliva the titers of IgA antibodies to Naegleria fowleri in the group of patients with URTI was significantly higher than that of the healthy group in the parasite-endemic area; also the titers of IgM antibodies in serum were significantly higher in patients. On the contrary, in saliva the antibodies were higher in healthy people from the parasite-endemic area. In all cases the subjects from the parasite-nonendemic area had lower antibody titers in serum and saliva.Key words: Naegleria fowleri, IgA, IgM antibodies, serum, saliva.

Des anticorps apparentant aux classes IgA et IgM reconnaissant des protéines de Naegleria fowleri (Nf) ont été détectés par la méthode ELISA dans le sérum et la salive de trois groupes de personnes: (i) des sujets souffrant d'infections des voies respiratoires supérieures (IVRS) et demeurant une région de parasitisme endémique, (ii) des personnes saines de la même région, et (iii) des personnes saines d'une région non endémique. Dans le sérum et la salive, les titres d'anticorps IgA dirigés contre Naegleria fowleri chez les membres du groupe de patients avec IVRS étaient significativement plus élevés que dans ceux du groupe sain provenant de la région de parasitisme endémique; en outre, les titres d'anticorps IgM sérique étaient significativement plus élevés chez les patients. En revanche, les anticorps dans la salive étaient plus abondants chez les personnes saines de la région endémique. Dans tous les cas, les sujets de la région non endémique avaient des titres d'anticorps plus bas dans le sérum et la salive.Mots clés : Naegleria fowleri, IgA, anticorps IgM, sérum, salive.[Traduit par la Rédaction]

Keywords: IgA; IgM antibodies; Naegleria fowleri; anticorps IgM; saliva; salive; serum; sérum

Document Type: Research Article

Publication date: 2001-05-01

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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