Comparison of the activity spectra against pathogens of bacterial strains producing a mutacin or a lantibiotic

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Abstract:

The increase of drug resistance among bacterial pathogens is currently a major threat in hospital settings. New and more efficient antibiotic compounds have to be developed to fight infectious diseases. In the present work, a deferred antagonism test was used to determine the activity of different bacterial strains producing either a mutacin or a lantibiotic against bacterial pathogens. The mutacins A, B, C, D, I, K, L, M, and nisins A and Z were active against all enterococci tested. Mutacins A and B, and nisins A and Z inhibited all the staphylococci tested. Except for the strains producing mutacins P, Q, and X, all the other producing strains inhibited the streptococci tested. Mutacins A, B, I, J, T, nisins A and Z, and epidermin inhibited the two antibiotic-resistant strains of Neisseria gonorrhoeae tested. Mutacins A, B, C, D, and nisins A and Z inhibited Campylobacter jejuni and Helicobacter pylori. Thus, the wide activity spectra of nisin A and Z are confirmed. These results also indicate that many of the mutacins, especially those of groups A, B, C, D, I, J, K, L, M, and T, could be candidates for further development as useful antibiotics.Key words: mutacin, lantibiotic, bacteriocin, antibiotic.

L'augmentation de la résistance aux antibiotiques parmi les bactéries pathogènes représente aujourd'hui une menace importante dans les milieux hospitaliers. De nouveaux composés antibiotiques plus efficaces doivent être conçus afin de combattre les maladies infectieuses. Dans l'étude présente, une analyse d'antagonisme différé fut utilisée dans le but de déterminer l'activité de différentes souches bactériennes produisant soit une mutacine, soit un lantibiotique agissant contre des bactéries pathogènes. Les mutacines A, B, C, D, I, K, L, M, de même que les nisines A et Z étaient actives contre tous les entérocoques testés. Les mutacines A et B, et les nisines A et Z ont inhibé tous les staphylocoques testés. À l'exception des souches produisant les mutacines P, Q et X, toutes les autres souches productrices ont inhibé les streptocoques testés. Les mutacines A, B, I, J, T, les nisines A et Z, et l'épidermine ont inhibé les deux souches de Neisseria gonorhoeae résistantes aux antibiotiques qui ont été testés. Les mutacines A, B, C, D, et les nisines A et Z ont inhibé Campylobacter jejuni et Helicobacter pylori. Ainsi, le large spectre d'action des nisines A et Z est confirmé. Ces résultats indiquent également que plusieurs des mutacines, en particulier celles des groupes A, B, C, D, I, J, K, L, M, et T, pourraient être des candidates pour des développements futurs en tant qu'antibiotiques utiles.Mots clés : mutacines, lantibiotiques, bactériocines, antibiotiques.[Traduit par la Rédaction]

Keywords: antibiotic; antibiotiques; bacteriocin; bactériocines; lantibiotic; lantibiotiques; mutacin; mutacines

Document Type: Research Article

Publication date: April 1, 2001

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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