Ability of Escherichia coli O157:H7 isolates to colonize the intestinal tract of conventional adult CD1 mice is transient

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Abstract:

In an attempt to improve upon a current mouse model of intestinal colonization by Escherichia coli O157:H7 used in this laboratory for vaccine development, nine clinical isolates of the pathogen were screened for their ability to persist in the intestinal tract of conventional adult CD-1 mice. None of the test isolates of E. coli O157:H7 were capable of colonizing these mice for a period of more than two weeks. Most of the isolates appeared to be benign for the experimental host, but one isolate was lethal. This virulence correlated with the ability of the latter isolate to produce large quantities of Shiga-like toxin 2 in vitro.

Dans une tentative d'améliorer un modèle murin actuel de colonisation intestinale par Escherichia coli O157:H7 utilisé dans ce laboratoire pour le développement de vaccins, neufs isolats cliniques du pathogène furent criblés selon leur capacité à persister dans le tractus intestinal de souris CD1 adultes conventionnelles. Aucun des isolats de E. coli O157:H7 testés ne furent capables de coloniser ces souris sur une période de plus de deux semaines. La plupart des isolats semblèrent être bénins pour l'hôte expérimental, mais un isolat fut létal. Cette virulence montra une corrélation avec la capacité du dernier isolat à produire d'importantes quantités de toxine simili-Shiga 2 in vitro.[Traduit par la Rédaction]

Document Type: Research Article

Publication date: January 1, 2001

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  • Published since 1954, this monthly journal contains new research in the field of microbiology including applied microbiology and biotechnology; microbial structure and function; fungi and other eucaryotic protists; infection and immunity; microbial ecology; physiology, metabolism and enzymology; and virology, genetics, and molecular biology. It also publishes review articles and notes on an occasional basis, contributed by recognized scientists worldwide.
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