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Postconsumption domoic acid generation by the diatom Pseudo-nitzschia multiseries as a factor in depuration models

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A theoretical analysis of the clearance of the neurotoxin domoic acid (DA) from molluscan shellfish, notably the blue mussel (Mytilus edulis), indicated that the depuration simulation did not account for the maximum accumulation of DA nor for the failure to eliminate all of the DA from the mussels in the anticipated time. Subsequent examination of relatively young, neurotoxin-producing cells of Pseudo-nitzschia multiseries concentrated 8.5- to 10-fold and reincubated in the dark, however, showed significant amounts of DA were produced within the first 24h of incubation. The possible production of DA, after ingestion, could generate an additional contribution to the toxin burden in the mollusc, which, when included in the depuration simulation, would explain part or all of the observed disparity in the depuration experiment.

Une analyse théorique de la clearance de l’acide domoïque (DA), une neurotoxine chez les mollusques comestibles, particulièrement chez la moule bleue (Mytilus edulis), indique que la simulation de la dépuration n’explique pas l’accumulation maximale de DA, ni le fait que la totalité de DA n’est pas éliminée des moules dans le temps prévu. Un examen subséquent de cellules productrices de neurotoxine relativement jeunes de Pseudo-nitzschia multiseries, concentrées par un facteur de 8,5 à 10 et incubées de nouveau à l’obscurité, montre qu’il y a une production d’importantes quantités de DA durant les premières 24 h de l’incubation. La production possible de DA après l’ingestion pourrait ajouter une contribution supplémentaire à la charge de toxine du mollusque qui, une fois incluse dans la simulation de dépuration, expliquerait en totalité ou en partie la disparité observée au cours de l’expérience de dépuration.

Document Type: Research Article

Publication date: September 1, 2008

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  • Published continuously since 1901 (under various titles), this monthly journal is the primary publishing vehicle for the multidisciplinary field of aquatic sciences. It publishes perspectives (syntheses, critiques, and re-evaluations), discussions (comments and replies), articles, and rapid communications, relating to current research on cells, organisms, populations, ecosystems, or processes that affect aquatic systems. The journal seeks to amplify, modify, question, or redirect accumulated knowledge in the field of fisheries and aquatic science. Occasional supplements are dedicated to single topics or to proceedings of international symposia.
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