Authors: Rasalkar, Meghana S.; Bhilare, Sachin V.; Deorukhkar, Amol R.; Darvatkar, Nitin B.; Salunkhe, Manikrao M.

Source: Canadian Journal of Chemistry, Volume 85, Number 1, January 2007 , pp. 77-80(4)

Publisher: NRC Research Press

Abstract:

This paper describes a one-pot three-component Mannich reaction, catalyzed by phosphotungstic acid (H₃PW₁₂O₄₀), a heteropoly acid in ionic liquid. The catalyst was found to be mild and efficient, and the protocol affords β-amino ketones in good yields under ambient conditions. Several ionic liquids and conventional organic solvents were employed for the reaction. The ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF₄) offered the best results in terms of yield of the products. It was observed that a homogeneous reaction medium proved beneficial for the yield of the reaction.Key words: Mannich reaction, β-amino ketones, phosphotungstic acid, ionic liquid, recyclability.

Dans ce travail on a réalisé une réaction de Mannich monotope à trois composants, catalysée par l'acide phosphotungstique (H₃PW₁₂O₄₀), un hétéropolyacide, dans un milieu ionique. On a trouvé que ce catalyseur est doux et efficace et que la méthode conduit à la formation de β-aminocétones avec de bons rendements, en opérant dans des conditions ambiantes. Pour réaliser cette réaction, on a utilisé plusieurs liquides ioniques ainsi que plusieurs solvants organiques conventionnels. Le liquide ionique du nom de tétrafluoroborate de 1-butyl-3-méthylimidazolium ([bmim]BF₄) est celui qui donne les meilleurs résultats en terme de rendement des produis. On a observé que le milieu réactionnel homogène s'avère utile pour le rendement de la réaction.Mots-clés : réaction de Mannich, β-aminocétones, acide phosphotungstique, liquide ionique, possibilité de recycler.[Traduit par la Rédaction]

Document Type: Research article

Publication date: 2007-01-01

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• In this Subject: Chemistry (General) ,  Inorganic Chemistry ,  Organic Chemistry
• By this author: Rasalkar, Meghana S. ;  Bhilare, Sachin V. ;  Deorukhkar, Amol R. ;  Darvatkar, Nitin B. ;  Salunkhe, Manikrao M.

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