Association of insulin sensitivity and muscle strength in overweight and obese sedentary postmenopausal women

Authors: Karelis, Antony D.; Tousignant, Benoit; Nantel, Julie; Proteau-Labelle, Majorique; Malita, Florin M.; St-Pierre, David H.; Brochu, Martin; Doucet, Eric; Rabasa-Lhoret, Rémi

Source: Applied Physiology, Nutrition, and Metabolism, Volume 32, Number 2, April 2007 , pp. 297-301(5)

Publisher: NRC Research Press

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Abstract:

The objective of this study was to examine the relationship between insulin sensitivity and lower body muscle strength in overweight and obese sedentary postmenopausal women. The design of the study was cross-sectional. The study population consisted of 82 non-diabetic overweight and obese sedentary postmenopausal women (age: 58.2± 5.1y; body mass index (BMI): 32.4± 4.6kg·m^-2). Subjects were classified by dividing the entire cohort into quartiles based on relative insulin sensitivity expressed per kilograms of lean body mass (LBM) (Q1,< 10.3, vs. Q2, 10.3-12.4, vs. Q3, 12.5-14.0, vs. Q4,>14.0mg·min^-1·kg LBM^-1). We measured insulin sensitivity (using the hyperinsulinemic-euglycemic clamp technique), body composition (using dual-energy X-ray absorptiometry), visceral fat and muscle attenuation (using computed tomography), and a lower-body muscle strength index expressed as weight lifted in kilograms per kilogram of LBM (kg·kg LBM^-1) (using weight-training equipment). A positive and significant relationship was observed between insulin sensitivity and the muscle strength index (r = 0.37; p< 0.001). Moreover, a moderate but significant correlation was observed between the muscle strength index and muscle attenuation (r = 0.22; p< 0.05). Finally, the muscle strength index was significantly higher in the Q4 group compared with the Q2 and Q1 groups, respectively (3.78± 1.13 vs. 2.99± 0.77 and 2.93± 0.91kg·kg LBM^-1; p< 0.05). Insulin sensitivity is positively associated with lower-body muscle strength in overweight and obese sedentary postmenopausal women.

Le but de cette étude est d'analyser la relation entre la sensibilité à l'insuline et la force musculaire des membres inférieurs chez des femmes présentant un surpoids et chez des femmes obèses postménopausées et sédentaires. Nous utilisons une approche transversale auprès d'un échantillon constitué de 82 femmes postménopausées, sédentaires, un peu trop pesantes et obèses mais non diabétiques (âge: 58,2 ± 5,1 ans; IMC: 32,4 ± 4,6kg·m^-2 ) que nous répartissons dans quatre quartiles selon leur sensibilité à l'insuline exprimée en fonction de leur masse maigre (LBM): Q1: <10,3, Q2: 10,3-12,4, Q3: 12,5-14,0 et Q4: >14,0mg·min^-1· kg LBM^-1). Nous mesurons la sensibilité à l'insuline au moyen de la technique du clamp euglycémique hyperinsulinémique, la composition corporelle par absorptiométrie à rayons X en double énergie, le contenu viscéral de gras et de l'atrophie musculaire par tomographie assistée par ordinateur et la force musculaire des membres inférieurs par la charge soulevée à une appareil de musculation; cette dernière est exprimée en kilogrammes par kilogrammes de LBM. Nous observons une relation positive significative entre la sensibilité à l'insuline et l'indice de force musculaire (r = 0,37; p < 0,001). En outre, nous observons une relation modérée mais significative entre l'indice de force musculaire et l'atrophie musculaire (r = 0,22; p < 0,05). Finalement, nous observons chez le groupe Q4 un meilleur indice de force musculaire que chez les groupes Q2 et Q1: (3,78 ± 1,13 comparativement à 2,99 ± 0,77 et à 2,93 ± 0,91 kg·kg LBM^-1; p < 0,05), respectivement. On observe une relation positive entre la sensibilité à l'insuline et la force des membres inférieurs chez des femmes postménopausées sédentaires présentant un surpoids et obèses.

Document Type: Research article

Publication date: 2007-04-01

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This bimonthly journal has a 30-year history of publishing, first as the Canadian Journal of Sport Sciences, and later as the Canadian Journal of Applied Physiology. It publishes original research articles, reviews, and commentaries, focussing on the application of physiology, nutrition, and metabolism to the study of human health, physical activity, and fitness. The published research, reviews, and symposia will be of interest to exercise physiologists, physical fitness and exercise rehabilitation specialists, public health and health care professionals, as well as basic and applied physiologists, nutritionists, and biochemists.
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Association of insulin sensitivity and muscle strength in overweight and obese sedentary postmenopausal women

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