Authors: McMillan, Kathleen P.; Kuk, Jennifer L.; Church, Timothy S.; Blair, Steven N.; Ross, Robert

Source: Applied Physiology, Nutrition, and Metabolism, Volume 32, Number 2, April 2007 , pp. 265-272(8)

Publisher: NRC Research Press

Abstract:

The independent associations between liver fat, visceral adipose tissue (AT), and metabolic risk factors are unclear. Although it has been reported that visceral AT is the strongest predictor of metabolic risk, liver fat has also been reported as a strong independent associate of a deleterious metabolic profile. We examined the independent associations between liver fat, visceral AT, and metabolic risk factors in a sample of 293 men varying widely in adiposity. Liver fat and abdominal AT were measured by computed tomography (CT). Univariate analysis revealed that liver fat was associated (p< 0.05) with triglycerides (TG), systolic blood pressure (SBP), and total cholesterol (TC), but not with glucose or high-density lipoprotein cholesterol (HDLC). Liver fat remained a significant correlate (p< 0.05) of TG and TC after control for age and subcutaneous AT or cardiorespiratory fitness (CRF), but not after adjustment for visceral AT alone. Conversely, visceral AT remained significantly associated with TG, SBP, glucose, HDLC (p< 0.01), and TC (p = 0.05) independent of liver fat, subcutaneous AT, CRF, and age. Both liver fat and visceral AT were associated with metabolic risk in men. However, when controlled for each other, visceral AT was the only independent associate of metabolic risk.

Les relations indépendantes entre le gras hépatique, le tissu adipeux viscéral (AT) et les facteurs de risque métaboliques ne sont pas bien comprises. Bien que des études aient pointé le tissu adipeux viscéral comme étant le plus important facteur de risque métabolique, d'autres études établissent que le gras hépatique est un facteur très important du dérèglement du métabolisme. Le but de cet étudeet l'analyse des relations indépendantes entre le gras hépatique, le tissu adipeux viscéral et les facteurs de risque métabolique chez 293 hommes dont le degré d'adiposité varie beaucoup. Nous avons évalué le contenu adipeux du foie et du tissu adipeux viscéral par tomodensitométrie (CT). L'analyse univariée montre que le gras hépatique est associé (p < 0,05) à la concentration des triglycérides (TG), à la pression systolique (SBP) et au cholestérol total (TC), mais pas à la concentration de glucose ni à la concentration des lipoprotéines à haute densité (HDLC). Le contenu hépatique de gras demeure un corrélat significatif (p < 0,05) des TG, du TC et de la capacité cardiorespiratoire (CRF) après avoir apporté la correction pour l'âge et le degré de tissu adipeux sous-cutané, mais pas après la correction pour le contenu viscéral de gras uniquement. D'autre part, le contenu viscéral de gras demeure significativement associé aux TG, à la SBP, au glucose et au HDLC (p < 0,01) et au TC (p= 0,05) indépendamment du contenu hépatique de gras, du tissu adipeux sous-cutané, de la CRF et de l'âge. Le contenu hépatique de gras et le contenu viscéral de tissu adipeux sont tous les deux associés au dérèglement du métabolisme chez les hommes. Par contre, après correction pour chacune des variables, le contenu viscéral de tissu adipeux est le seul facteur indépendant associé au dérèglement du métabolisme.

Document Type: Research article

Publication date: 2007-04-01

More about this publication?

• This bimonthly journal has a 30-year history of publishing, first as the Canadian Journal of Sport Sciences, and later as the Canadian Journal of Applied Physiology. It publishes original research articles, reviews, and commentaries, focussing on the application of physiology, nutrition, and metabolism to the study of human health, physical activity, and fitness. The published research, reviews, and symposia will be of interest to exercise physiologists, physical fitness and exercise rehabilitation specialists, public health and health care professionals, as well as basic and applied physiologists, nutritionists, and biochemists.
• Information for Authors
• Submit a Paper
• Subscribe to this Title
• Terms & Conditions
• Sample Issue
• Reprints & Permissions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• In this Subject: Nutrition & Food ,  Anatomy & Physiology
• By this author: McMillan, Kathleen P. ;  Kuk, Jennifer L. ;  Church, Timothy S. ;  Blair, Steven N. ;  Ross, Robert

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers