Authors: Lichtenberger, P.¹; Rosa-Cunha, I.¹; Morris, M.¹; Nishida, S.²; Akpinar, E.²; Gaitan, J.³; Tzakis, A.²; Doblecki-Lewis, S.¹

Source: Transplant Infectious Disease, Volume 11, Number 2, April 2009 , pp. 137-142(6)

Publisher: Wiley-Blackwell

Abstract:

P. Lichtenberger, I. Rosa-Cunha, M. Morris, S. Nishida, E. Akpinar, J. Gaitan, A. Tzakis, S. Doblecki-Lewis. Hyperinfection strongyloidiasis in a liver transplant recipient treated with parenteral ivermectin.

Transpl Infect Dis 2009: 11: 137-142. All rights reserved Abstract:

Severe strongyloidiasis, including hyperinfection and dissemination, is a recognized complication of solid organ transplantation. However, the development of strongyloidiasis in a liver transplant recipient has not been previously described. We present a case of severe strongyloidiasis occurring in a patient 4 months after liver transplantation and 1 month after receiving treatment for acute rejection. We assess the management challenges in this patient who remained symptomatic despite oral treatment with ivermectin and albendazole and eventual successful treatment with parenteral ivermectin. We review the published experience with alternative methods of ivermectin administration. We also investigate the possible source of infection, as the patient was not from an endemic area.

Keywords: liver transplantation; Strongyloides stercoralis; severe strongyloidiasis; parenteral ivermectin

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-3062.2008.00358.x

Affiliations: 1: Department of Medicine, Division of Infectious Diseases, 2: Department of Surgery, Division of Liver and Gastrointestinal Transplantation, and 3: Department of Pathology, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA

Publication date: 2009-04-01

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