Bronchiolitis obliterans organizing pneumonia associated with Pneumocystis jiroveci infection in orthotopic liver transplantation

Authors: Almaslmani, M.¹; Derbala, M.F.; Albozom, I.²; Khattab, M.¹; Chacko, K.¹; Alani, A.³

Source: Transplant Infectious Disease, Volume 10, Number 5, October 2008 , pp. 339-342(4)

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Abstract:

M. Almaslmani, M.F. Derbala, I. Albozom, M. Khattab, K. Chacko, A. Alani. Bronchiolitis obliterans organizing pneumonia associated with Pneumocystis jiroveci infection in orthotopic liver transplantation.

We report a patient who presented 6 months after orthotopic liver transplantation (OLT) with fever, dyspnea, and pulmonary infiltrates with biopsy-confirmed Pneumocystis jiroveci infection associated with a process of bronchiolitis obliterans organizing pneumonia (BOOP). We present this second case of BOOP associated with P. carinii pneumonia after OLT to highlight the risk of such disease combination in all transplant patients as well as discuss the protective effect of post-transplant prednisolone with trimethoprim-sulfamethoxazole prophylaxis and the possible duration of prophylaxis.

Keywords: brochiolitis obliterans organizing pneumonia (BOOP; Pneumocystis jiroveci; PCP; liver transplantation

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-3062.2008.00300.x

Affiliations: 1: Department of Medicine, Infectious Disease, Doha, State of Qatar, 2: Department of Laboratory Medicine and Histopathology, Doha, State of Qatar, 3: Department of Internal Medicine, Hamad Medical Corporation, Doha, State of Qatar

Publication date: 2008-10-01