Generation of the B*41 group of alleles as indicated by intron sequences

Authors: Martínez-Laso, J.; Moscoso, J.¹; Zamora, J.¹; Gómez-Casado, E.¹; Arnaiz-Villena, A.

Source: Tissue Antigens, Volume 67, Number 1, January 2006 , pp. 70-74(5)

Publisher: Blackwell Publishing

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Abstract:

The generation of the B*41 alleles has been analysed using exon 1, intron 1, exon 2, intron 2 and exon 3 sequences. Results showed that B*4102 may have been generated as the first B*41 allele by a recombination mechanism between B*400102 and B*0801 or B*4201 involving intron 2. B*4101, B*4104 and B*4107 alleles could have been generated from B*4102 by a gene conversion event taking three different fragments from sequences belonging to intron 2/exon 3 of B*45, B*50 or B*49 alleles. B*4105 and B*4106 could be generated from B*4101 allele by point mutations, and B*4103 generation is unclear due to the lack of intron 2. The importance of introns in HLA-B allele polymorphism generation is stressed.

Keywords: Gene conversion; HLA-B; intron; MHC; recombination

Document Type: Research article

DOI: 10.1111/j.1399-0039.2005.00499.x

Affiliations: 1: Department of Immunology, Universidad Complutense, Madrid, Spain

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