Strategies for evaluating B*18 allelic diversity by sequence-based typing applied to studies of a population from Singapore and African-Americans

Authors: Hou, L.¹; Tu, B.¹; Ling, G.¹; Tang, T.¹; Cao, K.²; Steiner, N. K.²; Lazaro, A.²; Ng, J.¹; Hartzman, R. J.³; Hurley, C. K.²

Source: Tissue Antigens, Volume 67, Number 1, January 2006 , pp. 66-69(4)

Publisher: Wiley-Blackwell

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Abstract:

Strategies to resolve B*18 alleles which carry a deletion in intron 1 close to the 5′ end of exon 2 relative to other HLA-B alleles or a null allele mutation in exon 1 and to resolve ambiguities among allele combinations including B*18 are described. B*18 allele frequencies from volunteer donors recruited for two hematopoietic stem cell registries show the presence of two alleles, B*180101 and B*1802, in a population from Singapore and only B*180101 in African-Americans.

Keywords: allele frequency; HLA-B

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-0039.2005.00503.x

Affiliations: 1: Department of Pediatrics, Georgetown University, Washington, DC, USA 2: Department of Oncology, Georgetown University, Washington, DC, USA 3: Naval Medical Research Center, Kensington, MD, USA

Publication date: 2006-01-01