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A stochastic model for transepidermal drug delivery

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Abstract:

Background:

Topical drug application has been widely used to manage skin diseases as well as to treat a variety of local and systemic disorders. To evaluate the efficiency of transepidermal drug delivery, an efficient model is needed to study the process of percutaneous transport. Model description:

A stochastic model based on Monte Carlo methods and Cellular Automata is presented in this work to study the molecular transport through the stratum corneum of the human skin, which is a typical process in transepidermal drug delivery. Methods:

To validate the model, an in vitro experiment on percutaneous absorption of radioactive 17-estradiol was performed. Results and discussion:

The simulation results agree with the experimental data. Conclusion:

The use and power of the presented approach in studying the process of transepidermal drug delivery were demonstrated.

Keywords: Cellular Automata; Monte Carlo methods; percutaneous absorption; stochastic model; stratum corneum; transepidermal drug delivery

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0846.2009.00378.x

Affiliations: 1: Department of Medical Microbiology, Department of Textile Sciences, University of Manitoba, Winnipeg, MB, Canada , 2: Department of Mechanical and Manufacturing Engineering, University of Manitoba, Winnipeg, MB, Canada and 3: Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA

Publication date: 2009-11-01

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