Authors: Hathout, Eba¹; Alonso, Estella²; Anand, Ravinder³; Martz, Karen³; Imseis, Essam⁴; Johnston, Joyce¹; Lopez, James⁵; Chinnock, Richard¹; McDiarmid, Sue⁶

Source: Pediatric Transplantation, Volume 13, Number 5, August 2009 , pp. 599-605(7)

Publisher: Wiley-Blackwell

Abstract:

Hathout E, Alonso E, Anand R, Martz K, Imseis E, Johnston J, Lopez J, Chinnock R, McDiarmid S. Post-transplant diabetes mellitus in pediatric liver transplantation.

Pediatr Transplantation 2009: 13: 599-605. © 2007 John Wiley & Sons A/S. Abstract: 

To determine the characteristics of pediatric liver transplant recipients who develop GI and/or PTDM, data on children undergoing their first liver transplant from the SPLIT database were analyzed (n = 1611). Recipient and donor characteristics that were evaluated included age at transplant, gender, race, primary disease, hospitalization status at transplant, BMI, recipient and donor CMV status, donor type, donor age, and primary immunosuppression. GI/PTDM was found in 214 individuals (13%) of whom 166 (78%) were diagnosed within 30 days of transplantation (early GI/PTDM). Multivariate analyses suggests that age >5 yr at transplant, hospitalization at transplant, a primary diagnosis other than BA, early steroid use, and tacrolimus use are associated with increased incidence of early GI. Routine monitoring for the development of GI and post-transplant diabetes is indicated in the short- and long-term care of children after liver transplantation.

Keywords: post-transplant diabetes; pediatrics; liver transplantation; islets; immunosuppression

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-3046.2007.00603.x

Affiliations: 1: Division of Pediatric Endocrinology and Diabetes, Loma Linda University, Loma Linda, CA 2: Division of Pediatric Gastroenterology, Northwestern University, Chicago, IL 3: EMMES, Rockville, MD 4: Division of Pediatric Gastroenterology, Ochsner Clinic Foundation, New Orleans, LA 5: Division of Pediatric Gastroenterology, University of Michigan, Ann Arbor, MI 6: Division of Pediatric Gastroenterology, UCLA, Los Angeles, CA, USA

Publication date: 2009-08-01

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