Authors: Michaels, Marian G.¹; Fonseca-Aten, Monica²; Green, Michael¹; Charsha-May, Deborah³; Friedman, Barry; Seikaly, Mouin²; Sánchez, Pablo J.²

Source: Pediatric Transplantation, Volume 13, Number 4, June 2009 , pp. 451-456(6)

Publisher: Wiley-Blackwell

Abstract:

Michaels MG, Fonseca-Aten M, Green M, Charsha-May D, Friedman B, Seikaly M, Sánchez PJ. Respiratory syncytial virus prophylaxis: A survey of pediatric solid organ transplant centers.

Pediatr Transplantation 2009:13:451-456. © 2008 John Wiley & Sons A/S Abstract: 

RSV can cause respiratory illness after SOT, yet preventive recommendations are lacking for this population. To ascertain current preventive practices against RSV disease in pediatric SOT candidates and recipients, a survey was developed. The survey was mailed to 108 SOT programs in the United States (liver, 42; heart, 28; lung, 11; intestinal, 25; and heart-lung, 2). Results were tabulated and analyzed using standard methods. Sixty-two percent (67/108) of surveys were completed. Forty-nine percent (33/67) of programs reported using RSV prophylaxis; palivizumab was used at 97% (32/33) of centers with 26 giving palivizumab to candidates and 27 to recipients. Prophylaxis was provided to infants aged 0-12 months by 27/29 (93%) of responding centers; 23/29 of centers extended its use to infants aged 0-24 months. Three centers gave prophylaxis to children between ages two and four yr and two centers for those over four yr. RSV prophylactic strategies, and in particular the use of palivizumab, are employed by almost 50% of responding pediatric SOT centers. Strategies varied at centers based on age and organ type. Data on RSV hospitalization and outcome are needed to refine approaches to RSV immunoprophylaxis in these high-risk patients.

Keywords: solid organ transplantation; pediatric transplantation; respiratory syncytial virus; palivizumab

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-3046.2008.01017.x

Affiliations: 1: Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA 2: Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA 3: MedImmune, Gaithersburg, MD, USA

Publication date: 2009-06-01

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