Authors: Yui, Yoshihiro¹; Umeda, Katsutsugu¹; Kaku, Haruna¹; Arai, Masato¹; Hiramatsu, Hidefumi¹; Watanabe, Ken-ichiro¹; Saji, Hiroh²; Adachi, Souichi¹; Nakahata, Tatsutoshi¹

Source: Pediatric Transplantation, Volume 11, Number 5, August 2007 , pp. 543-546(4)

Publisher: Wiley-Blackwell

Abstract:

Yui Y, Umeda K, Kaku H, Arai M, Hiramatsu H, Watanabe K.I, Saji H, Adachi S, Nakahata T. A pediatric case of transfusion-related acute lung injury following bone marrow infusion.

Pediatr Transplantation 2007: 11: 543-546. © 2007 Blackwell Munksgaard Abstract: 

TRALI is a rare but serious complication associated with transfusion, and known to occur following infusion of all types of plasma-containing blood products. However, only one adult case of TRALI after allogenic marrow graft has been reported. In this study, we present a pediatric case possibly associated with allogenic marrow infusion. A 10-yr-old girl was referred to our hospital for the treatment of acute myeloid leukemia. She underwent allogenic bone marrow transplantation from her HLA-2-loci-mismatched mother. During conditioning, she suffered from bacterial sepsis, but it had improved with antibiotics until day 0 of transplantation. Two h after starting the marrow infusion, she developed severe hypoxia. We discontinued the infusion and started steroids, which improved her respiratory condition. However, she developed respiratory failure again after resuming infusion of the graft. Despite intensive care with mechanical ventilation, the patient died of endotoxin shock five days after transplantation. Although we could not identify the antibody which might have been involved in the respiratory distress, the clear temporal relationship between marrow infusion and respiratory distress suggested that similar acute lung injury to TRALI might have occurred following allogenic marrow infusion in the present case.

Keywords: transfusion-related acute lung injury; bone marrow transplantation

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-3046.2007.00745.x

Affiliations: 1: Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan 2: NPO (Non-profit organization), HLA laboratory, Kyoto, Japan

Publication date: 2007-08-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Pediatrics ,  Surgery
• By this author: Yui, Yoshihiro ;  Umeda, Katsutsugu ;  Kaku, Haruna ;  Arai, Masato ;  Hiramatsu, Hidefumi ;  Watanabe, Ken-ichiro ;  Saji, Hiroh ;  Adachi, Souichi ;  Nakahata, Tatsutoshi

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers