Authors: Stankova, Jitka; Carret, Anne-Sophie; Moore, Dorothy¹; McCusker, Christine²; Mitchell, David³; Davis, Michael⁴; Mazer, Bruce²; Jabado, Nada³

Source: Pediatric Transplantation, Volume 11, Number 2, March 2007 , pp. 209-213(5)

Publisher: Wiley-Blackwell

Abstract:

Stankova J, Carret A-S, Moore D, McCusker C, Mitchell D, Davis M, Mazer B, Jabado N. Long-term therapy with aerosolized ribavirin for parainfluenza 3 virus respiratory tract infection in an infant with severe combined immunodeficiency.

Pediatr Transplantation 2006. © 2006 Blackwell Munksgaard Abstract: 

We report the case of an infant with severe combined immunodeficiency who was presented with PIV3 infection. Aerosolized ribavirin was administered for 10 months until the child gained a functional immune system through an allogeneic hematopoietic stem cell transplant and cleared PIV3 infection. No adverse effect was observed in the child and in healthcare personnel, with a follow-up of three years. Despite the burden of aerosolized administration, early and prolonged administration of aerosolized ribavirin was feasible, well tolerated, and safe for the patient and the caregivers. This is a case report and no definite conclusions can be drawn. However, our experience suggests that prolonged aerosolized ribavirin administration should be considered for the treatment of PIV3 infection in the context of primary immunodeficiency, where there is no currently available alternative treatment, until a functional immune system is gained.

Keywords: severe combined immunodeficiency syndrome; parainfluenza 3; ribavirin; aerosolized; stem cell transplantation

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-3046.2006.00607.x

Affiliations: 1: Division of Infectious Diseases 2: Division of Allergy and Immunology 3: Division of Hematology and Oncology 4: Division of Respiratory Medicine, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada

Publication date: 2007-03-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Pediatrics ,  Surgery
• By this author: Stankova, Jitka ;  Carret, Anne-Sophie ;  Moore, Dorothy ;  McCusker, Christine ;  Mitchell, David ;  Davis, Michael ;  Mazer, Bruce ;  Jabado, Nada

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers