Inhaled 1,8-Cineole Reduces Inflammatory Parameters in Airways of Ovalbumin-Challenged Guinea Pigs
Authors: Bastos, Vasco P.D.; Gomes, Antoniella S.1; Lima, Francisco J.B.1; Brito, Teresinha S.1; Soares, Pedro M.G.2; Pinho, João P.M.1; Silva, Claudijane S.3; Santos, Armênio A.1; Souza, Marcellus H.L.P.1; Magalhães, Pedro J.C.1
Source: Basic & Clinical Pharmacology & Toxicology, Volume 108, Number 1, January 2011 , pp. 34-39(6)
Eucalyptol, also known as 1,8-cineole, is a monoterpene traditionally used to treat respiratory disorders due to its secretolytic properties. In addition to its myorelaxant effects, it also has anti-inflammatory actions in vitro. In this study, we aimed to evaluate the efficacy of acute treatment with 1,8-cineole on reducing airway inflammatory parameters. Ovalbumin (OVA)-sensitized guinea pigs were submitted to antigenic challenge (OVA) with or without pre-treatment with a single dose of 1,8-cineole administered by inhalation. Airway inflammatory parameters were reduced or absent in 1,8-cineole-treated animals as compared with untreated guinea pigs. Acute treatment with 1,8-cineole impaired the development of airway hyperresponsiveness to carbachol in isolated tracheal rings. Levels of the pro-inflammatory cytokines TNFα and IL-1β was lower in bronchoalveolar lavage fluid (BALF) of 1,8-cineol-treated guinea pigs than in untreated animals. 1,8-Cineole impaired the OVA-induced increase of the myeloperoxidase activity in BALF. 1,8-Cineole also prevented the reduction of the mucociliary clearance induced by the antigen presentation. The present investigation provides evidence that inhaled 1,8-cineole prevents hyperresponsiveness and inhibits inflammation in airways of ovalbumin-challenged guinea pigs.
Document Type: Research Article
Affiliations: 1: Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil 2: Department of Morphology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil 3: Faculdade Integrada do Ceará, Fortaleza, CE, Brazil
Publication date: 2011-01-01
- Formerly Pharmacology & Toxicology
- In this: publication
- By this: publisher
- In this Subject: Ecology , Pharmacology , Toxicology
- By this author: Bastos, Vasco P.D. ; Gomes, Antoniella S. ; Lima, Francisco J.B. ; Brito, Teresinha S. ; Soares, Pedro M.G. ; Pinho, João P.M. ; Silva, Claudijane S. ; Santos, Armênio A. ; Souza, Marcellus H.L.P. ; Magalhães, Pedro J.C.