Skip to main content

Levosimendan Interacts with Potassium Channel Blockers in Human Saphenous Veins

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Abstract:

The involvement of potassium channels in the venodilating capacity of the inodilator levosimendan in human saphenous vein preparations was investigated. Levosimendan caused relaxation with 50% effective concentration (EC50) of 0.32±0.04 μM in isolated veins contracted by 5-hydroxytryptamine. Fifteen μM glibenclamide, a blocker of the ATP-sensitive potassium channels (KATP), partially inhibited the relaxing effect of the inodilator. In the presence of iberiotoxin, the selective blocker of large conductance calcium-activated potassium channels (BKCa), levosimendan induced contraction with EC50 of 0.21±0.06 μM. We presume that levosimendan dilates human saphenous veins by interacting with hyperpolarizing potassium channels (KATP and BKCa).

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1742-7843.2004.pto940603.x

Affiliations: 1: Department of Parmacology and Pharmacotherapy, 2: Department of Surgery, 3: Department of Medical Chemistry, Albert Szent-Györgyi Medical Center, University of Szeged, and

Publication date: 2004-06-01

More about this publication?
  • Formerly Pharmacology & Toxicology
  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more