Levosimendan Interacts with Potassium Channel Blockers in Human Saphenous Veins
The involvement of potassium channels in the venodilating capacity of the inodilator levosimendan in human saphenous vein preparations was investigated. Levosimendan caused relaxation with 50% effective concentration (EC50) of 0.32±0.04 μM in isolated veins contracted by 5-hydroxytryptamine. Fifteen μM glibenclamide, a blocker of the ATP-sensitive potassium channels (KATP), partially inhibited the relaxing effect of the inodilator. In the presence of iberiotoxin, the selective blocker of large conductance calcium-activated potassium channels (BKCa), levosimendan induced contraction with EC50 of 0.21±0.06 μM. We presume that levosimendan dilates human saphenous veins by interacting with hyperpolarizing potassium channels (KATP and BKCa).
Document Type: Research Article
Publication date: 2004-06-01
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- Formerly Pharmacology & Toxicology