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Levosimendan Interacts with Potassium Channel Blockers in Human Saphenous Veins

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Abstract:

The involvement of potassium channels in the venodilating capacity of the inodilator levosimendan in human saphenous vein preparations was investigated. Levosimendan caused relaxation with 50% effective concentration (EC50) of 0.32±0.04 μM in isolated veins contracted by 5-hydroxytryptamine. Fifteen μM glibenclamide, a blocker of the ATP-sensitive potassium channels (KATP), partially inhibited the relaxing effect of the inodilator. In the presence of iberiotoxin, the selective blocker of large conductance calcium-activated potassium channels (BKCa), levosimendan induced contraction with EC50 of 0.21±0.06 μM. We presume that levosimendan dilates human saphenous veins by interacting with hyperpolarizing potassium channels (KATP and BKCa).
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Document Type: Research Article

Affiliations: 1: Department of Parmacology and Pharmacotherapy, 2: Department of Surgery, 3: Department of Medical Chemistry, Albert Szent-Györgyi Medical Center, University of Szeged, and

Publication date: 2004-06-01

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