The Preservatives Ethyl-, Propyl- and Butylparaben are Oestrogenic in an in vivo Fish Assay

Authors: Pedersen K.L.; Pedersen S.N.; Christiansen L.B.; Korsgaard B.; Bjerregaard P.

Source: Basic & Clinical Pharmacology & Toxicology, Volume 86, Number 3, 1 March 2000 , pp. 110-113(4)

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Abstract:

The widely used phenolic preservatives ethylparaben, propylparaben, butylparaben and their common metabolite p-hydroxybenzoic acid were tested for their ability to evoke an oestrogenic response in vivo. Yolk protein induction in sexually immature rainbow trout was used as an oestrogen-specific endpoint after repeated injections of the compounds. All tested parabens were oestrogenic in doses between 100 and 300 mg/kg, while the metabolite showed no activity. Ethylparaben was found to be approximately sixty times weaker than propyl- and butylparaben which had oestrogenic potencies comparable to those previously found for bisphenol A.

Document Type: Original article

Affiliations: 1: Danish Center for Environmental Oestrogen Research, Institute of Biology, USD Odense University, Campusvej 55,DK-5230 Odense M, Denmark

Publication date: 2000-03-01

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