Skip to main content

The effect of ultraviolet radiation from a novel portable fluorescent lamp on serum 25‐hydroxyvitamin D3 levels in healthy adults with Fitzpatrick skin types II and III

Buy Article:

$43.00 plus tax (Refund Policy)

Summary
Background/Purpose

Ultraviolet (UV) B irradiation may provide a safe and effective method to treat vitamin D deficiency. The objective of this study was to assess the effectiveness of a novel Sperti D/UV‐Fluorescent lamp in converting 7‐dehydrocholesterol (7‐DHC) to previtamin D3 in vitro and in raising serum 25‐hydroxyvitamin D3 [25(OH)D3] in healthy adults.
Methods

The lamp was assessed in vitro using a 7‐DHC solution and a human skin sample. In a prospective cohort study, five healthy adults with skin types II and III were exposed to a 0.75 minimal erythemal dose of UV radiation over ∼9% of body surface area three times a week for 4 weeks. The main outcomes were percentage of conversion from 7‐DHC to previtamin D3 in vitro and changes in serum 25(OH)D3 after irradiation in vivo.
Results

A dose response between UV irradiation time and conversion of 7‐DHC to previtamin D3 was seen in the 7‐DHC solution and surgically obtained human skin. The subjects had a significant increase in mean 25(OH)D3 from 18.4 ± 8.2 to 27.3 ± 7.6 ng/ml (P < 0.001) after 4 weeks of irradiation. No adverse events occurred.
Conclusion

The Sperti D/UV‐Fluorescent lamp is effective in converting 7‐DHC to previtamin D3 in vitro and in raising serum 25(OH)D3 in healthy adults.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Publication date: 2012-12-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more