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The effect of ultraviolet radiation from a novel portable fluorescent lamp on serum 25‐hydroxyvitamin D3 levels in healthy adults with Fitzpatrick skin types II and III

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Abstract:

Summary
Background/Purpose

Ultraviolet (UV) B irradiation may provide a safe and effective method to treat vitamin D deficiency. The objective of this study was to assess the effectiveness of a novel Sperti D/UV‐Fluorescent lamp in converting 7‐dehydrocholesterol (7‐DHC) to previtamin D3 in vitro and in raising serum 25‐hydroxyvitamin D3 [25(OH)D3] in healthy adults.
Methods

The lamp was assessed in vitro using a 7‐DHC solution and a human skin sample. In a prospective cohort study, five healthy adults with skin types II and III were exposed to a 0.75 minimal erythemal dose of UV radiation over ∼9% of body surface area three times a week for 4 weeks. The main outcomes were percentage of conversion from 7‐DHC to previtamin D3 in vitro and changes in serum 25(OH)D3 after irradiation in vivo.
Results

A dose response between UV irradiation time and conversion of 7‐DHC to previtamin D3 was seen in the 7‐DHC solution and surgically obtained human skin. The subjects had a significant increase in mean 25(OH)D3 from 18.4 ± 8.2 to 27.3 ± 7.6 ng/ml (P < 0.001) after 4 weeks of irradiation. No adverse events occurred.
Conclusion

The Sperti D/UV‐Fluorescent lamp is effective in converting 7‐DHC to previtamin D3 in vitro and in raising serum 25(OH)D3 in healthy adults.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/phpp.12000

Publication date: December 1, 2012

mksg/ppp/2012/00000028/00000006/art00006
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