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Preferential induction of endothelin-1 in a human epidermal equivalent model by narrow-band ultraviolet B light sources

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Abstract:

Narrow-band ultraviolet B (NB-UVB; 310–315 nm) is commonly used to treat vitiligo, but the mechanisms underlying the therapeutic effect have not been understood completely. Here, we evaluated the effects of broadband UVB (BB-UVB), NB-UVB, 308 nm xenon chloride (XeCl) excimer laser, and 308 nm XeCl excimer light on the expression of endothelin-1 (ET-1) in a cultured human epidermal tissue model. Our results provide a theoretical basis for the effectiveness of UVB irradiation, including excimer light and excimer laser, in the treatment of vitiligo.

Keywords: 308 nm XeCl excimer laser; 308 nm XeCl excimer light; broad-band UVB; endothelin-1; human epidermal tissue model; narrow-band UVB

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0781.2010.00510.x

Affiliations: Department of Geriatric and Environmental Dermatology, Nagoya City University of Medical Sciences, Nagoya, Japan

Publication date: June 1, 2010

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