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Local effects of TL01 phototherapy in psoriasis

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Abstract:

The mechanisms whereby narrowband ultraviolet B (UVB) (311–313 nm, TL01) phototherapy are effective in psoriasis may differ from those occurring in broadband UVB phototherapy. In the present study, changes in epidermal cells as a result of TL01 therapy were assessed in the skin of patients with psoriasis. The non-lesional skin of five subjects with plaque psoriasis was biopsied before and after a series of 12 whole-body TL01 treatments. Following appropriate staining of skin sections, the numbers of p53-positive keratinocytes, sunburn cells and Langerhans cells in the epidermis were counted. TL01 therapy induced a threefold increase in the number of p53-positive epidermal cells, a 12-fold increase in sunburn cells and a twofold decrease in Langerhans cells. The increase in epidermal p53 expression and apoptosis of keratinocytes together with the depletion of Langerhans cells in the non-lesional skin of psoriasis patients are likely to contribute to the effectiveness of TL01 phototherapy.

Keywords: Langerhans cells; TL01; p53; psoriasis; sunburn cells

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0781.2008.00366.x

Affiliations: 1: Department of Dermatology and 2: Department of Biomedical Sciences, University of Edinburgh, Edinburgh, UK

Publication date: October 1, 2008

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