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Clinical effect of vitamin D3 analogues is not inactivated by subsequent UV exposure

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Summary Background:

Combining phototherapy with topical vitamin D3 analogues is a useful therapy for the treatment of psoriasis by reducing the cumulative UV dose required for clearance of lesions. Experimental investigations demonstrated that calcipotriol is degraded by UV radiation, and suggested that calcipotriol should be applied after phototherapy but not immediately before. Methods:

Calcipotriol or maxacalcitol ointment was topically applied to psoriatic plaques of six patients immediately before or after phototherapy on the right or left side of the body, respectively. Results:

Topical application of vitamin D3 analogues either before or after irradiation by psoralen and UVA radiation (PUVA) or narrow-band (NB)-UVB showed exactly similar effects in all patients. Conclusion:

Therapeutic effects of vitamin D3 analogues are not clinically inactivated by subsequent irradiation with PUVA or NB-UVB phototherapy.
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Keywords: calcipotriol; maxacalcitol; phototherapy; psoriasis; vitamin D3 analogue

Document Type: Research Article

Affiliations: Department of Dermatology, Kanssai Medical University, Osaka, Japan

Publication date: 01 February 2008

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