Skip to main content

Lack of effect of oral selenite on p53 associated gene expression during TL01 therapy of psoriasis patients

Buy Article:

$43.00 plus tax (Refund Policy)

Selenium (Se) has protective properties against ultraviolet (UV)-induced changes in skin cells in vitro but little is known about such activity in human subjects. In the present study, seven patients with psoriasis ingested 400 g of sodium selenite daily during a 4 week course of whole-body narrow-band UVB (TL01) therapy while six more psoriasis patients, similarly irradiated, ingested a placebo. Skin biopsies, collected at the start and end of the phototherapy were analysed for phosphorylated p53, Fas, Bcl-2, Bax and oxidized guaninosine, and for numbers of Langerhans and sunburn cells. Following the TL01 therapy, no significant difference was observed for any of these markers when the Se group was compared with the placebo group of patients, although p53 and Bcl-2 expression decreased in the Se supplemented group.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Langerhans cells; UV-induced proteins; phototherapy; sodium selenite; sunburn cells

Document Type: Research Article

Affiliations: 1: Dermatology, 2: Clinical Biochemistry and 3: The Rowett Research Institute, Scotland, UK 4: Biomedical Sciences, University of Edinburgh, Edinburgh, UK

Publication date: 2007-04-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more