Skip to main content

Pain induced by photodynamic therapy of warts

Buy Article:

$43.00 plus tax (Refund Policy)


Photodynamic therapy with topical 5-aminolevulinic acid (ALA), followed by irradiation with red light (ALA-PDT), is used for non-melanoma skin cancer and other dermatological diseases. Pain during and after light exposure is a well-known adverse advent that may be a limiting factor for treatment, particularly, in viral warts. Methods:

To assess the pain induced by ALA-PDT, we asked 45 patients enrolled in a randomized, placebo-controlled trial with six consecutive ALA- and placebo-PDT treatments for recalcitrant foot and hand warts to fill in questionnaires about pain immediately and 24 h after each treatment. Results:

Immediately and 24 h after each of the six treatments, pain intensity was significantly higher in warts treated with ALA-PDT than in warts treated with placebo-PDT (P<0.028). Severe or unbearable pain was reported from a median of 17% (6–31%) of the ALA -treated warts and from a median of 2% (0–15%) from the placebo-treated warts immediately after the treatments. With increasing treatments, no significant change in pain intensity was observed and no significant relation was found between the pain intensity and the relative change in wart area. The pain was primarily characterized as burning and shooting. The pain lasted about 30 h (range: 1–96 h). Conclusion:

We conclude that pain induced by ALA-PDT is of such intensity in about one-fifth of the warts that pain relief is indicated.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: ALA; PpIx; fluorescence; pain; warts

Document Type: Research Article

Affiliations: 1: Department of Dermatology, H:S Copenhagen University, Copenhagen, Denmark, 2: Clinic for Pain, Department of Anesthesiology, Bispebjerg Hospital, H:S Copenhagen University, Copenhagen, Denmark, and 3: Copenhagen Trial Unit, Centre for Clinical Intervention Research, H:S Copenhagen University, Copenhagen, Denmark

Publication date: 2006-12-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more