Skip to main content

Open comedones overlying granuloma annulare in a photoexposed area

Buy Article:

$43.00 plus tax (Refund Policy)

A 57-year-old, fair-skinned female patient with lesions of granuloma annulare located on her forearms – with signs of actinic damage – is described. No response was observed after successive treatments with topical corticosteroids and oral pentoxifylline. Four years later, the patient developed open comedones on the rim of granuloma annulare lesions. The loss of elastic fibers seen in both granuloma annulare and solar elastosis is presumed to have induced the appearance of open comedones, because of a loss of supporting properties of the dermis inducing a distension of the infundibular canal of the sebaceous follicle, as seen in the Favre–Racouchot disease and actinic comedonal plaque. Concomitantly, the patient developed insulin-dependent diabetes mellitus. Treatment with insulin resulted in the disappearance of open comedones and notably regression of lesions of granuloma annulare. Response to insulin therapy in our case supports the hypothesis that insulinopenia could participate in the development of granuloma annulare in some cases.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: comedones; diabetes mellitus; granuloma annulare; solar elastosis

Document Type: Research Article

Affiliations: 1: Unidad de Dermatología Occidente, Universidad de Chile, Chile and 2: Vida Integra

Publication date: 2006-10-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more