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Comparison of the efficacy of calcipotriol and maxacalcitol in combination with narrow-band ultraviolet B therapy for the treatment of psoriasis vulgaris

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Abstract:

Background:

Combination treatment with topical vitamin D3 and narrow-band ultraviolet B (UVB) radiation is effective against psoriasis vulgaris. We compared the efficacy of the topical vitamin D3 derivatives calcipotriol and maxacalcitol in combination therapy. Materials and methods:

In this retrospective observational study, 21 patients admitted to Nagoya City University Hospital between April 2001 and September 2004 were enrolled. Results:

Combination treatment with calcipotriol or maxacalcitol and narrow-band UVB was effective against psoriasis vulgaris. Calcipotriol induced a more rapid improvement and required lower levels of narrow-band UVB irradiation to be effective. Serum calcium levels were slightly increased after 4 weeks of treatment, but there was no significant difference between the two groups. No other adverse effects were observed in either of the two groups. Conclusion:

The findings of this retrospective observational study indicated that combination treatment with topical vitamin D3 derivatives and narrow-band UVB is effective against psoriasis without any obvious side-effects. These findings provide further evidence that calcipotriol has advantages over maxacalcitol regarding the narrow-band UVB-accumulated treatment dose and improvement rate of psoriasis area and severity index (PASI) scores.

Keywords: calcipotriol; maxacalcitol; narrow-band UVB; psoriasis vulgaris; topical vitamin D3

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0781.2006.00247.x

Affiliations: Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

Publication date: October 1, 2006

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