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Skin surface topography grading is a valid measure of skin photoaging

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Abstract:

Background:

The technique of grading the surface topography of sun-exposed skin using silicone impressions of the skin surface is a simple, non-invasive method for measuring skin damage because of sun exposure, but it has never been validated in a community setting. Objective:

To investigate the repeatability and validity of using standardly-graded skin impressions as a means of assessing skin photoaging. Patients/Methods:

A random sample of 195 adults aged 18–79 years and living in Nambour, Australia (latitude, 26° South) had a silicone impression taken of the back of the left hand and a 2 mm punch biopsy of the skin at the same site. Silicone impressions were graded twice independently and histological photoaging was determined by two pathologists. Results:

Grading of silicone impressions of skin surface topography was highly repeatable (weighted >0.8). Compared with those with low skin impression grades (least degeneration), people with high grades were three times more likely to show a high degree of dermal elastosis on skin histology (odds ratio 3.1, 95% confidence interval 1.6, 5.7) after adjusting for age, sex, skin colour, tanning ability, occupational exposure, smoking and height-adjusted weight. Other photoaging changes in the stratum corneum and dermis were also strongly correlated with high grades of damage on skin impressions. Conclusion:

Grading silicone impressions of skin surface topography is a highly reliable and a valid measure of photoaging and enables prediction of dermal elastosis in a population setting.

Keywords: dermal elastosis; photoaging; skin surface topography; ultraviolet radiation

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0781.2006.00194.x

Affiliations: 1: Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Qld, Australia, 2: Princess Alexandra Hospital, Brisbane, Qld, Australia, and 3: L'Oréal Recherche, France

Publication date: 2006-02-01

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