Skip to main content

Oral PUVA and topical steroids for treatment of oral manifestations of chronic graft-vs.-host disease

Buy Article:

$51.00 plus tax (Refund Policy)



Oral manifestations of chronic graft-vs.-host disease (cGVHD) can significantly affect the quality of life and severity often does not correlate with systemic manifestations. We evaluated the use of topical corticosteroids and the intraoral application of psoralen-UVA (PUVA) for treatment of oral manifestations of cGVHD. Methods:

Overall, 18 patients with oral manifestations of cGVHD were treated with either intraoral PUVA (n=7) or with topical corticosteroids (n=16). Four patients received intraoral PUVA after failure of topical steroids and one patient was treated with topical corticosteroids after failing treatment with intraoral PUVA. A glass fiber extension of an UVA source was used for manual intraoral application. Treatment with topical corticosteroids consisted of 0.1 mg/ml dexamethasone mouth wash four times a day in combination with antifungal prophylaxis. Results:

Four patients showed complete local response (CR) due to intraoral PUVA, two improved and one did not respond. Topical corticosteroids resulted in nine patients in CR, two improved and five did not respond. Conclusion:

Intraoral PUVA as well as topical corticosteroids are effective in treatment of oral manifestations of oral GVHD with few side-effects and improve quality of life in patients with cGVHD.

Keywords: PUVA; chronic GVHD; oral mucosa; topical steroids

Document Type: Research Article


Affiliations: 1: Division of Haematology and Oncology, Department of Medicine, University of Rostock, Rostock, Germany, 2: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and 3: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, and 4: Eastern Virginia Medical School, Norfolk, VA, USA

Publication date: August 1, 2004


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more