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The characteristics of erythema induced by topical 5-aminolaevulinic acid photodynamic therapy

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Abstract:

Background:

Topical photodynamic therapy (PDT) is increasingly used to treat superficial non-melanoma skin cancers. Knowledge of the characteristics of 5-aminolaevulinic acid (ALA)-induced phototoxicity will increase our understanding of PDT and may facilitate optimisation of treatment regimes. Methods:

We examined the characteristics of ALA-induced erythema in 10 healthy subjects and investigated the effect of light source and body site. Results and Conclusion:

Maximal erythema occurred within 1–2 h of PDT and inter-individual variation in ALA-induced phototoxicity was seen. No detectable differences were seen in the phototoxicity on back or leg sites or between coherent and non-coherent light sources. These data provide further information to allow us to optimise topical PDT regimes.

Keywords: 5-aminolaevulinic acid; erythema; fluorescence; minimal phototoxic dose; photodynamic therapy

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0781.2004.00085.x

Publication date: 2004-04-01

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