Skip to main content

Iron chelation can modulate UVA-induced lipid peroxidation and ferritin expression in human reconstructed epidermis

Buy Article:

$43.00 plus tax (Refund Policy)


As ferritin has been identified as an important factor in antioxidant defense in cultured human skin cells, we evaluated UVA-induced lipid hydroperoxides (LPO) production and ferritin expression in reconstructed human epidermis in vitro. Results:

Ferritin is regularly present in the basal layer of unirradiated epidermis both in the human skin in vivo and in the reconstructed human epidermis in vitro. Following acute UVA exposure, ferritin expression increased in basal epidermal cells in both models. Quantitative analysis showed that, in reconstructed human epidermis, LPO and ferritin levels increased linearly with the UVA dose. An iron chelator, OR10141, inhibited these inductions. Conclusion:

These findings demonstrate that reconstructed human epidermis is a useful in vitro model to study UVA-induced oxidative stress and protection afforded by iron chelators, antioxidants or UVA absorbers.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: UVA; episkin®; ferritin; iron chelator; lipid peroxidation; reconstructed human epidermis

Document Type: Research Article

Affiliations: 1: L'Oréal Recherche, Clichy, France, and 2: L'Oréal Recherche, Aulnay-sous-bois, France

Publication date: 2004-02-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more