Iron chelation can modulate UVA-induced lipid peroxidation and ferritin expression in human reconstructed epidermis

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Abstract:

Background/Purpose:

As ferritin has been identified as an important factor in antioxidant defense in cultured human skin cells, we evaluated UVA-induced lipid hydroperoxides (LPO) production and ferritin expression in reconstructed human epidermis in vitro. Results:

Ferritin is regularly present in the basal layer of unirradiated epidermis both in the human skin in vivo and in the reconstructed human epidermis in vitro. Following acute UVA exposure, ferritin expression increased in basal epidermal cells in both models. Quantitative analysis showed that, in reconstructed human epidermis, LPO and ferritin levels increased linearly with the UVA dose. An iron chelator, OR10141, inhibited these inductions. Conclusion:

These findings demonstrate that reconstructed human epidermis is a useful in vitro model to study UVA-induced oxidative stress and protection afforded by iron chelators, antioxidants or UVA absorbers.

Keywords: UVA; episkin®; ferritin; iron chelator; lipid peroxidation; reconstructed human epidermis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0781.2004.00064.x

Affiliations: 1: L'Oréal Recherche, Clichy, France, and 2: L'Oréal Recherche, Aulnay-sous-bois, France

Publication date: February 1, 2004

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