Skip to main content

Cutaneous effects of infrared radiation: from clinical observations to molecular response mechanisms

Buy Article:

$43.00 plus tax (Refund Policy)

Human skin is exposed to infrared (IR) radiation (760 nm–1 mm) from natural as well as artificial sources that are increasingly used for cosmetic or medical purposes. Epidemiological data and clinical observations, however, indicate that IR radiation cannot be considered as totally innocuous to human skin. In particular, IR radiation, similar to ultraviolet radiation, seems to be involved in photoaging and potentially also in photocarcinogenesis. The molecular consequences resulting from IR exposure are virtually unknown. Recent studies, however, have begun to shed light on the basic molecular processes such as cellular signal transduction and gene expression triggered by exposure to IR radiation. In response to IR irradiation, mitogen-activated protein kinase signaling pathways were activated mediating the upregulation of matrix metalloproteinase-1 expression. This previously unrecognized molecular ‘IR response’ shows that IR radiation is capable of specifically interfering with cellular functions and provides a molecular basis for biological effects of IR on human skin.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: infrared; matrix metalloproteinases; mitogen-activated protein kinases; photoaging

Document Type: Research Article

Affiliations: Institut fuer Umweltmedizinische Forschung (IUF) an der Heinrich-Heine-Universitaet gGmbH, Auf'm Hennekamp 50, D-40225 Duesseldorf, Germany,

Publication date: 2003-10-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more