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The pathophysiology of photosensitivity in lupus erythematosus

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The strong association between photosensitivity and lupus erythematosus has led to the suggestion that abnormal photoreactivity participates in the pathogenesis of cutaneous lesions. In this review we discuss the evidence for abnormal cutaneous reactivity to sunlight in lupus and speculate on the cellular, molecular and genetic factors that may underlie this abnormality.
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Keywords: TNF α; apoptosis; heat shock protein; lupus erythematosus; photosensitivity

Document Type: Research Article

Affiliations: 1: Division of Dermatology, Faculty of Medicine, University of British Columbia, and Vancouver Hospital and Health Science Center, Vancouver BC, Canada 2: Department of Dermatology, University of Iowa Hospitals and Clinics/University of Iowa Health Care, Iowa City, Iowa, USA

Publication date: 2001-06-01

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