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Neoplastic transformation of neonatal human fibroblasts exposed in vitro to radiation from a quartz‐halogen lamp

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The use of unfiltered quartz‐halogen lamps exposes human skin to radiation that spans much of the ultraviolet (UV) spectrum. Reports indicate that exposure to quartz‐halogen lamps is erythemogenic, mutagenic, and carcinogenic. To compare the carcinogenic potential of quartz‐halogen lamps with that of other UV sources, we determined the dose dependence for cytotoxicity and neoplastic transformation in neonatal human fibroblasts exposed in vitro to: a 15 W germicidal lamp (primarily 254 nm radiation), a 15 W Cool White fluorescent lamp, and an unfiltered 20 W quartz‐halogen lamp. Fluence‐survival relationships were multiphasic with linear dose response below about 40% survival, and all three sources produced fluence‐dependent transformation as indicated by induction of anchorage‐independent growth. Maximum transformation frequencies were observed at fluences of 5–8 J/m2 for the germicidal lamp, 6.3 kJ/m2 for the fluorescent lamp, and 300 J/m2 for the quartz‐halogen lamp. These data confirm the carcinogenic potential of the quartz‐halogen lamp.

Document Type: Original Article


Affiliations: 1: National Center for Toxicological Research/FDA, Jefferson, Arkansas 2: Center for Devices and Radiological Health/FDA, Rockville, Maryland, USA

Publication date: 1995-06-01

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