Authors: Levitt Katz, Lorraine E.¹; Swami, Sanjeev¹; Abraham, Máire¹; Murphy, Kathryn M.¹; Jawad, Abbas F.²; McKnight-Menci, Heather¹; Berkowitz, Robert³

Source: Pediatric Diabetes, Volume 6, Number 2, June 2005 , pp. 84-89(6)

Publisher: Wiley-Blackwell

Abstract:

Levitt Katz LE, Swami S, Abraham M, Murphy KM, Jawad AF, McKnight-Menci H, Berkowitz R. Neuropsychiatric disorders at the presentation of type 2 diabetes mellitus in children. Objectives:

To estimate the frequency of neuropsychiatric disease (NPD) in an urban pediatric type 2 diabetes mellitus (T2DM) population, to compare demographic characteristics of affected patients with those unaffected with NPD, and to determine the frequency of psychotropic medication treatment. Study Design:

Retrospective chart review of patients with T2DM at the Children's Hospital of Philadelphia. Results:

Of 237 patients with T2DM, 46 (19.4%) were found to have NPD at the presentation of diabetes. Diagnoses by report included depression, attention-deficit hyperactivity disorder (ADHD), neurodevelopmental disorders, schizophrenia, and bipolar disorder. Those affected were 63% females and 37% males, with a mean age of 14.6 yr and body mass index (BMI) of 34.3 kg/m² at diagnosis of T2DM. Patients were 79% African American, 13% Caucasian, 4.3% Hispanic, and 4.3% Asian. There were no statistically significant differences in demographic characteristics or BMI between those affected and unaffected with NPD. Twenty-nine patients (63%) were on psychotropic medication and were prescribed 58 medications, most commonly mood stabilizers (n = 20) and atypical antipsychotics (n = 17). Conclusions:

Our data reveal a high frequency of NPD among pediatric patients with T2DM at presentation to a tertiary care, urban medical center. Many affected patients are receiving psychotropic medication. These data have implications for screening regimens for pediatric populations at high risk for T2DM and for therapeutic interventions, including lifestyle measures.

Keywords: atypical antipsychotics; depression; insulin resistance; obesity; type 2 diabetes mellitus

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-543X.2005.00105.x

Affiliations: 1: Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; 2: Division of Biostatistics and Epidemiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; 3: Division of Psychiatry, The Children's Hospital of Philadelphia, Philadelphia, PA, USA

Publication date: 2005-06-01

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