The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT): initial aims and impact of the family history of type 1 diabetes mellitus in Japanese children
Authors: Matsuura N.1; Yokota Y.1; Kazahari K.1; Sasaki N.2; Amemiya S.3; Ito Y.4; Fukushima N.5; Koike A.6; Igarashi Y.7; Hirano T.8; Sugihara S.9; Miki Y.10; Urakami T.11; Uchigata Y.12; Kanematsu S.12; Ohki Y.13; Takesue M.14; Hasegawa Y.15; Miyamoto S.16; Fujimoto M.17; Fujitsuka S.18; Mori T.19; Ogawa H.20; Uchiyama M.21; Onigata K.22; Tachibana K.23; Kikuchi N.24; Taketani T.25; Kohno H.26; Kasahara Y.27; Isshiki G.28; Tokuda M.29; Takahashi T.30; Kanzaki S.31; Yokota I.32; Kida K.33; Okada T.34; Nishiyama S.35; Masuda H.36; Kinugasa A.37; Nukada O.38
Source: Pediatric Diabetes, Volume 2, Number 4, December 2001 , pp. 160-169(10)
Publisher: Blackwell Publishing
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Abstract:
Matsuura N, Yokota Y, Kazahari K, Sasaki N, Amemiya S, Ito Y, Fukushima N, Koike A, Igarashi Y, Hirano T, Sugihara S, Miki Y, Urakami T, Uchigata Y, Kanematsu S, Ohki Y, Takesue M, Hasegawa Y, Miyamoto S, Fujimoto M, Fujitsuka S, Mori T, Ogawa H, Uchiyama M, Onigata K, Tachibana K, Kikuchi N, Taketani T, Kohno H, Kasahara Y, Isshiki I, Tokuda M, Takahashi T, Kanzaki S, Yokota I, Kida K, Okada T, Nishiyama S, Masuda H, Kinugasa H, Nukada O. The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT): initial aims and impact of the family history of type 1 diabetes mellitus in Japanese children.Pediatric Diabetes 2001: 2: 160–169. © Munksgaard, 2001Abstract:
The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT) was established in July 1994 with the chief aim to improve the quality of therapy for type 1 diabetes in children, an entity far less common in Japan than in Europe. We proposed four initial research topics: (i) to determine the current status of medical care and glycemic control in Japanese children with type 1 diabetes mellitus; (ii) to standardize the measurement of hemoglobin A1c; (iii) to establish a registry of a large cohort of patients in order to enable prospective studies to improve the quality of therapy for children with type 1 diabetes in Japan; and (iv) to enable participants of the JSGIT to hold a workshop twice annually.
We registered a total of 736 patients from 45 hospitals throughout Japan. Intervention via insulin treatment was instituted after 2 yr for those patients whose hemoglobin A1c level was more than 8.1%. The proportion of patients receiving multiple insulin injections increased after intervention; however, average hemoglobin A1c in females remained significantly higher than in males. We identified two forms of diabetes in Japanese children: a rapidly progressive form and a more slowly progressive form. There was a significantly higher prevalence of a family history of diabetes in first-degree relatives in the slowly progressive form. These preliminary findings are the result of the first collaborative study of childhood diabetes in Japan.
Keywords: childhood and adolescent diabetes; family history of diabetes; insulin therapy; slowly progressive type 1 diabetes; standardization of hemoglobin A1c
Language: English
Document Type: Original article
DOI: 10.1034/j.1399-5448.2001.20404.x
Affiliations: 1: Department of Pediatrics, Kitasato University, 10: Tokyo University, 11: Nihhon University, 12: Tokyo Women's Medical University, 13: Nippon Medical School, 14: Musashino Red-Cross Hospital, 15: Tokyo Kiyose Metroplitan Children's Hospital, 16: Chiba Children's Hospital, 17: St. Marianna University, 18: National Defence Medical Collage, 19: Shinshu University, 2: Saitama Medical School, 20: Hamamatsu University, 21: Niigata University, 22: Gumma University, 23: Kanagawa Children's Medical Center, 24: Yokohama CityUniversity, 25: Kurobe Municipal Hospital, 26: Fukuoka Children's Hospital, 27: Kanazawa University, 28: Osaka City University, 29: Osaka Medical College, 3: Yamanashi Medical University, 30: Osaka Hospital, 31: Okayama University, 32: Tokushima University, 33: Ehime University, 34: Kochi Medical School, 35: Kumamoto University, 36: Mie National Hospital, 37: Kyoto Prefectural University of Medicine and 38: Kobe City West Municipal Hospital 4: Asahikawa Medical College, 5: Sapporo Municipal Hospital, 6: Kounan General Hospital, 7: Tohoku University, 8: Ibaragi Children Hospital, 9: Chiba University, *
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