Authors: Du Toit, G.¹; Santos, A.¹; Roberts, G.²; Fox, A. T.¹; Smith, P.³; Lack, G.¹

Source: Pediatric Allergy and Immunology, Volume 20, Number 4, June 2009 , pp. 309-319(11)

Publisher: Wiley-Blackwell

Abstract:

Du Toit G, Santos A, Roberts G, Fox AT, Smith P, Lack G. The diagnosis of IgE-mediated food allergy in childhood.

Pediatr Allergy Immunol 2009: 20: 309-319.

© 2009 The Authors

Journal compilation © 2009 Blackwell Munksgaard

IgE-mediated food allergy is a common condition in childhood and a recognized public health concern. An accurate diagnosis of food allergy facilitates the avoidance of the allergen - and cross-reactive allergens - and allows for safe dietary expansion. The diagnosis of food allergy relies on a combination of rigorous history, physical examination, allergy tests [skin prick tests (SPT) and/or serum-specific IgE] and oral food challenges. Diagnostic cut-off values for SPT and specific IgE results have improved the diagnosis of food allergy and thereby reduced the need to perform oral food challenges. This clinical case series seeks to highlight a contemporary approach to the diagnosis of food allergy in children strategies.

Keywords: allergy diagnosis; children, food allergy; food hypersensitivity; likelihood ratios; oral food challenge; skin prick testing; specific IgE

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-3038.2009.00887.x

Affiliations: 1: MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK, Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, UK 2: Paediatric Allergy and Respiratory Medicine, University Child Health, Southampton University Hospital NHS Trust, Southampton, UK 3: Clinical Medicine, Bond University, Robina and Griffiths University, Southport, Qld, Australia

Publication date: 2009-06-01

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