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IL-10 gene polymorphism, but not TGF-β1 gene polymorphisms, is associated with food allergy in a Japanese population
Authors: Campos Alberto, Eduardo Jose1; Shimojo, Naoki1; Suzuki, Yoichi2; Mashimo, Yoichi2; Arima, Takayasu1; Matsuura, Tomoko1; Inoue, Yuzaburo1; Yamaide, Akiko3; Tomiita, Minako1; Fujii, Katsunori1; Hata, Akira2; Kohno, Yoichi1
Source: Pediatric Allergy and Immunology, Volume 19, Number 8, December 2008 , pp. 716-721(6)
Publisher: Wiley-Blackwell
Abstract:
Campos Alberto EJ, Shimojo N, Suzuki Y, Mashimo Y, Arima T, Matsuura T, Inoue Y, Yamaide A, Tomiita M, Fujii K, Hata A, Kohno Y. IL-10 gene polymorphism, but not TGF-β1 gene polymorphisms, is associated with food allergy in a Japanese population.Pediatr Allergy Immunol 2008: 19: 716-721.© 2008 The AuthorsJournal compilation © 2008 Blackwell Munksgaard The regulatory IL-10 and TGF-β1 cytokine gene polymorphisms have been associated with allergic diseases in different populations, like Caucasian, Chinese and Indians. We investigated the association between the polymorphisms IL-10 A−1082G, C−819T, C−627A and TGF-β1 T+869C, G+915C, C−509T and food allergy in Japanese children. One hundred and eleven children with food allergy and 115 atopic control children without food allergy were recruited. DNA samples from these subjects were genotyped by using PCR. The odds ratio of IL-10 −1082 AA genotype was 2.5 (95% CI, 1.0-6.4) for food allergy risk when compared with atopic control subjects (p = 0.03). There were no significative differences in the frequency of TGF-β1 gene polymorphisms between both groups. Our results indicate that IL-10 A−1082G gene polymorphism is associated with food allergy susceptibility in atopic Japanese children.Keywords: IL-10; TGF-β1; food allergy; gene; polymorphism; transcription factor
Document Type: Research article
DOI: http://dx.doi.org/10.1111/j.1399-3038.2007.00709.x
Affiliations: 1: Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan 2: Department of Public Health, Graduate School of Medicine, Chiba University, Chiba, Japan 3: Chiba Children's Hospital, Chiba, Japan
Publication date: 2008-12-01
- In this: publication
- By this: publisher
- In this Subject: Allergy & Immunology , Pediatrics
- By this author: Campos Alberto, Eduardo Jose ; Shimojo, Naoki ; Suzuki, Yoichi ; Mashimo, Yoichi ; Arima, Takayasu ; Matsuura, Tomoko ; Inoue, Yuzaburo ; Yamaide, Akiko ; Tomiita, Minako ; Fujii, Katsunori ; Hata, Akira ; Kohno, Yoichi
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