Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

Authors: Benninghoff, Ulrike¹; Cattaneo, Federica¹; Aiuti, Alessandro¹; Flores-D'Arcais, Alberto²; Gelmetti, Carlo³; Viscardi, Matteo²; Callegaro, Luciano¹; Mirolo, Massimiliano¹; Ambrosi, Alessandro⁴; Roncarolo, Maria Grazia; Bacchetta, Rosa¹

Source: Pediatric Allergy and Immunology, Volume 19, Number 6, September 2008 , pp. 564-568(5)

Publisher: Wiley-Blackwell

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Abstract:

Benninghoff U, Cattaneo F, Aiuti A, Flores-D'Arcais A, Gelmetti C, Viscardi M, Callegaro L, Mirolo M, Ambrosi A, Roncarolo MG, Bacchetta R. Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome.

Pediatr Allergy Immunol 2008: 19: 564-569.

We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.

Keywords: interferon-α; hyper-IgE syndrome; cytokines; immunodeficiency; eczema

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-3038.2007.00683.x

Affiliations: 1: Pediatric Clinical Research Unit, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan Italy 2: Department of Pediatric Endocrine Unit, Vita-Salute University, Milan Italy 3: Department of Pediatric Dermatology, ''Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena'', Institute of Dermalogic Sciences, Università degli studi, Milan Italy 4: University Centre of Statistics for Biomedical Sciences, Vita-Salute University, Milan Italy

Publication date: 2008-09-01

Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

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