Educational clinical case series in pediatric allergy and immunology

Authors: Khan, Seema; Kandula, Leena¹; Orenstein, Susan R.²

Source: Pediatric Allergy and Immunology, Volume 18, Number 7, November 2007 , pp. 629-639(11)

Publisher: Wiley-Blackwell

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Abstract:

Khan S, Kandula L, Orenstein SR. Educational clinical case series in pediatric allergy and immunology.

Pediatr Allergy Immunol 2007: 18: 629-639.

Eosinophilic inflammation may occur in any part of the intestinal tract from the esophagus to the rectum. Despite 70 yr having passed since the first reference to a case of eosinophilic gastroenteritis, the epidemiology and natural history of eosinophilic gastrointestinal disorders are still poorly known. Insights into their etiology and pathogenesis have revealed an important role for allergens; interleukins 4, 5, and 13; the eotaxin family of chemokines; and eosinophil-derived proteins. Diagnosis is confirmed by typical histologic features in a patient with a suggestive clinical phenotype. Treatment involves eliminating triggering allergens, making dietary restrictions the first choice of therapy in a compliant patient; corticosteroids [topical in eosinophilic esophagitis (EE)], despite the potential for serious side effects, are used with success in refractory and non-compliant patients. In this study we discuss EE and gastroduodenitis against the backdrop of clinical case presentations.

Keywords: eosinophilia; esophagitis; gastroenteritis

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-3038.2007.00659.x

Affiliations: 1: Division of Pediatric Gastroenterology, Chapel Hill, NC, USA 2: Pediatric Gastroenterology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Publication date: 2007-11-01