Food-dependent exercise-induced anaphylaxis in childhood

Author: Toit, George Du

Source: Pediatric Allergy and Immunology, Volume 18, Number 5, August 2007 , pp. 455-463(9)

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Abstract:

Toit GD. Food-dependent exercise-induced anaphylaxis in childhood.

The clinical syndrome of food-dependent exercise-induced anaphylaxis (FDEIA) is typified by the onset of anaphylaxis during (or soon after) exercise which was preceded by the ingestion of the causal food allergen/s. In FDEIA, both the food allergen/s and exercise are independently tolerated. FDEIA is an uncommon allergic condition in childhood, but nonetheless is an important differential diagnosis to be considered when faced by a child who has experienced exercise-associated anaphylaxis. The diagnosis of FDEIA is heavily dependent on the clinical history. Allergy tests may need to be performed to a broad panel of food and food additives. Modified exercise challenges (performed with and without prior ingestion of food) are frequently required as allergy test results frequently return low-positive results. A diagnosis of FDEIA facilitates the safe independent return to exercise and reintroduction of foods for patients who otherwise may unnecessarily avoid exercise and/or restrict their diet. The natural history of FDEIA is unknown; however, a safe return is usually achieved when the ingestion of the causal food allergen/s and exercise are separated.

Keywords: food allergy; exercise; food-dependent exercise-induced anaphylaxis; exercise-induced anaphylaxis; wheat allergy

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-3038.2007.00599.x

Publication date: 2007-08-01